C. difficile is a bacteria considered to be responsible for approximately 25% of the diarrhoea associated with the consumption of antibiotics. In addition to these symptoms, the disease can lead to other complications (such as pseudomembranous colitis – PMC) that require urgent antibiotic treatment, as they can be life-threatening. In fact, mortality associated with C. difficile can reach up to 30%.
In the diagnosis of C. difficile infection, it is recommended to test all samples for GDH antigen if the origin of the diarrhoea is unknown. In case of a positive GDH antigen test, a second test for toxin A and/or B is recommended.
One-step immunochromatographic tests for the differential detection of Glutamate Dehydrogenase (GDH) as well as C. difficile toxins A and B in human faeces.

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