According to the Breast Cancer Information Core (BIC), there are more than 3,000 kinds of BRCA1 and BRCA2 gene mutations, distributing throughout the whole coding region. The most common types of pathogenic mutations are frameshiftmutations, nonsense mutations, while there are no obvious mutation hotspots. Most mutations lead to the formation oftruncated proteins, by which resulting in the loss of BRCA1 or BRCA2 protein function and lead to the occurrence of tumor.

Detection Significance
1. Assess family genetic risk and provides comprehensive, accurate, professional and precise diagnosis for tumordiagnosis and treatment.
2.To evaluate the response of patients with BRCA1 / 2 mutant malignant tumors to PARP inhibitors such as olapani.

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